Title : Kinetic characterization of the proteinase binding defect in a reactive site variant of the serpin, antithrombin. Role of the P1' residue in transition-state stabilization of antithrombin-proteinase complex formation.

Pub. Date : 1995 Apr 28

PMID : 7730349






1 Functional Relationships(s)
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Protein Name
Organism
1 AT-Denver inhibited thrombin and Factor Xa with nearly equimolar stoichiometries and formed SDS-stable complexes with these proteinases, indicating that the diminished inhibitor activity was not due to an enhanced turnover of the inhibitor as a substrate. Sodium Dodecyl Sulfate serpin family C member 1 Homo sapiens