Title : Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation.

Pub. Date : 1995 Apr 21

PMID : 7721822






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Squalene synthetase (SQS, EC 2.5.1.21) catalyzes the first committed step in the formation of cholesterol and thus represents an ideal site for selectively inhibiting sterol formation. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens
2 Squalene synthetase (SQS, EC 2.5.1.21) catalyzes the first committed step in the formation of cholesterol and thus represents an ideal site for selectively inhibiting sterol formation. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens