Pub. Date : 1995 Mar 28
PMID : 7702611
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of cytochrome P450 (Cyp1a-1) induction in mouse hepatoma Hepa-1C1C7 cells by methoxsalen. | Methoxsalen | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Cultured mouse hepatoma cell line Hepa-1c1c7 cells were treated with methoxsalen to assess the role of methoxsalen in the process of Cyp1a-1 induction. | Methoxsalen | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | We find that treatment of Hepa-1c1c7 cells with methoxsalen inhibited CYP1A1 mRNA induction by TCDD as well as the concomitant increase P4501A1 protein. | Methoxsalen | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Formation of DNA-protein complexes between the dioxin receptor and its DRE target was inhibited by methoxsalen, as determined by gel mobility shift assays using oligonucleotides corresponding to DRE 3 of the Cyp1a-1 gene. | Methoxsalen | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |