Title : Structural features important for the biological activity of the potassium channel blocking dendrotoxins.

Pub. Date : 1993 Oct

PMID : 7694758






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The region containing two of the disulphide bonds (around Cys5-Cys55 and Cys30-Cys51) and much of the secondary structure is essential for the binding affinity of the toxins, while the region around Cys14 and Cys38, equivalent to part of the antiprotease site of the homologous protease inhibitor from bovine pancreas (BPTI), plays an important role in the potency of dendrotoxins. disulphide spleen trypsin inhibitor I Bos taurus