Pub. Date : 1993 Nov 1
PMID : 7693857
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 and other cyclic AMP elevating agents inhibit interleukin 2 gene transcription by counteracting calcineurin-dependent pathways. | Dinoprostone | interleukin 2 | Homo sapiens |
| 2 | We have previously shown that prostaglandin E2 and other cAMP elevating agents inhibit the nuclear transcription of the human IL-2 gene by interfering with a Ca(2+)-sensitive T cell signal transduction pathway. | Dinoprostone | interleukin 2 | Homo sapiens |
| 3 | We report here that PGE2 markedly reduces the IL-2 promoter activity that is induced by a constitutively active form of calcineurin. | Dinoprostone | interleukin 2 | Homo sapiens |
| 4 | In contrast to the complete inhibition of promoter activity produced by the immunosuppressants cyclosporin A and FK-506, this partial block suggests that PGE2 modulates downstream events needed for lymphokine gene activation. | Dinoprostone | interleukin 2 | Homo sapiens |