Title : Effects of 5-aza-2'-deoxycytidine on differentiation and oncogene expression in the human monoblastic leukemia cell line U-937.

Pub. Date : 1993 May

PMID : 7683359






1 Functional Relationships(s)
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1 Molecular events induced by 5-aza-2"-deoxycytidine included a decrease in DNA methylation, along with a dramatic, permanent reduction in the levels of c-myc transcripts; both these events were detectable early (24 to 48 hours) after the start of drug administration. Decitabine MYC proto-oncogene, bHLH transcription factor Homo sapiens