Title : Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.

Pub. Date : 1993 Jan

PMID : 7678701






11 Functional Relationships(s)
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1 Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
3 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
4 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
5 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
6 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
7 In normal fibroblasts, the product of the cellular src gene, p60c-src or Src, is repressed by phosphorylation at its C-terminal tyrosine residue, Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
8 The tyrosine kinases that phosphorylate Src at Tyr 527 in vivo have not been identified, but a tyrosine kinase known as CSK is an excellent candidate. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
9 CSK has the unusual ability to phosphorylate Src in vitro only at Tyr 527. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
10 To examine whether CSK has the appropriate sequence specificy to explain the phosphorylation of Src at Tyr 527 in fibroblasts, we have made use of a set of C-terminal substitution mutants of Src. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
11 The other mutant Src molecules tested were not phophorylated by CSK, even though some of these mutants are highly phosphorylated at Tyr 527 in Rat 2 cells. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus