Title : Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase.

Pub. Date : 1995 Sep 15

PMID : 7662974






4 Functional Relationships(s)
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1 Although the induction of synthesis and early accumulation of cyclin E and cyclin E-associated kinase activity appeared normal, the appearance of cyclin A and cyclin A-associated kinase activity were inhibited by DFO. Deferoxamine cyclin A2 Homo sapiens
2 Although the induction of synthesis and early accumulation of cyclin E and cyclin E-associated kinase activity appeared normal, the appearance of cyclin A and cyclin A-associated kinase activity were inhibited by DFO. Deferoxamine cyclin A2 Homo sapiens
3 However, the production of cyclin A mRNA appeared to be normal in the presence of DFO. Deferoxamine cyclin A2 Homo sapiens
4 A major effect of DFO in blocking cell cycle progression may be mediated through inhibition of the appearance of cyclin A protein and, therefore, a major component of p33cdk2 activity. Deferoxamine cyclin A2 Homo sapiens