Title : A structure-based multiple sequence alignment of all class I aminoacyl-tRNA synthetases.

Pub. Date : 1995

PMID : 7647112






1 Functional Relationships(s)
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1 The conservation of those residues which have been shown to be critical in some aaRS enables to predict their location and function in the other synthetases, particularly: i) a conserved negatively-charged residue which binds the alpha-amino group of the amino acid substrate; ii) conserved residues within the inserted domain bridging the two halves of the dinucleotide-binding fold; and iii) conserved residues in the second half of the fold which bind the amino acid and ATP substrate. Adenosine Triphosphate alanyl-tRNA synthetase 1 Homo sapiens