Title : Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants.

Pub. Date : 1995 Mar

PMID : 7630488






3 Functional Relationships(s)
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1 In oocytes expressing the NR1/2A subunits, ethanol (25, 50 and 100 mM) inhibited NMDA (100 microM)/glycine (10 microM) induced currents by 21, 31 and 47%; respectively. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 In the absence of ethanol, glycine enhanced NMDA-induced currents with an EC50 of 1.42 microM for the NR1/NR2A combination and 0.51 microM for the NR1/NR2C combination. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
3 In the absence of ethanol, glycine enhanced NMDA-induced currents with an EC50 of 1.42 microM for the NR1/NR2A combination and 0.51 microM for the NR1/NR2C combination. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis