Pub. Date : 1995 Aug 15
PMID : 7627962
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-Ethoxy-2"-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression. | Fluorouracil | thymidine phosphorylase | Homo sapiens |
| 2 | 5-Ethoxy-2"-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression. | Fluorouracil | thymidine phosphorylase | Homo sapiens |
| 3 | Since TP catalyzes the first step in the direct conversion of FUra to deoxyribonucleotides, its induction by IFN is a potential biochemical mechanism for the modulation of the antitumor activity of FUra. | Fluorouracil | thymidine phosphorylase | Homo sapiens |
| 4 | Since TP catalyzes the first step in the direct conversion of FUra to deoxyribonucleotides, its induction by IFN is a potential biochemical mechanism for the modulation of the antitumor activity of FUra. | Fluorouracil | thymidine phosphorylase | Homo sapiens |
| 5 | In contrast to the activity measured in cell extracts, however, thymine utilization by intact cells was increased less than 2-fold by IFN, suggesting that the metabolic activation of FUra by TP in the IFN-treated cells was similarly suboptimal. | Fluorouracil | thymidine phosphorylase | Homo sapiens |
| 6 | One of the compounds, the novel pyrimidine analogue 5-ethoxy-2"-deoxyuridine (EOdU), was found to be a substrate for the transferase reaction of TP, to have little or no direct cytotoxicity, to selectively increase the cellular levels of 5-fluoro-dUMP, to enhance the inhibitory effect of FUra on thymidylate synthase activity, and to potentiate the cytotoxicity of FUra and IFN in human colon carcinoma cells. | Fluorouracil | thymidine phosphorylase | Homo sapiens |