Title : Expression of the human sodium/proton exchanger NHE-1 in Xenopus laevis oocytes enhances sodium/proton exchange activity and establishes sodium/lithium countertransport.

Pub. Date : 1995 Apr

PMID : 7603840






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using the Xenopus laevis oocyte expression system we determined amiloride-sensitive Li+ uptake, a measure of Na+/H+ exchange, in oocytes injected with water or NHE-1 cRNA. Amiloride solute carrier family 9 member A1 Homo sapiens
2 Amiloride-sensitive Li+ uptake was three- to tenfold enhanced over control in NHE-1 cRNA-injected cells and was selectively inhibited by 0.01 microM HOE 694 [i.e. (3-methylsulphonyl-4-piperidinobenzoyl) guanidine methanesulphonate]. Amiloride solute carrier family 9 member A1 Homo sapiens
3 After acidification of oocytes from pH 7.7 to 6.8, amiloride-sensitive Li+ uptake was four- to tenfold higher in NHE-1 cRNA-injected cells than in controls. Amiloride solute carrier family 9 member A1 Homo sapiens