Title : In vivo expression of metallothionein in rat alveolar macrophages and type II epithelial cells following repeated cadmium aerosol exposures.

Pub. Date : 1995 Jul

PMID : 7597713






2 Functional Relationships(s)
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1 Following Cd administration, the level of MT-1 mRNA and MT-2 mRNA increased in each cell class but the response to Cd was three times greater in alveolar macrophages. Cadmium metallothionein 1 Rattus norvegicus
2 In conclusion, the present study has demonstrated that (1) alveolar macrophages and type II cells respond to in vivo Cd exposure by increasing MT protein and mRNA levels; (2) MT expression is greater in macrophages than in type II cells and correlates well with intracellular Cd concentration; and (3) the MT-2 mRNA to MT-1 mRNA ratio is cell and treatment specific. Cadmium metallothionein 1 Rattus norvegicus