Title : A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

Pub. Date : 1995 Dec 1

PMID : 7594530






1 Functional Relationships(s)
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1 To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. Tetradecanoylphorbol Acetate interleukin 6 receptor Homo sapiens