Pub. Date : 1995 Nov 3
PMID : 7592869
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506, an immunosuppressant that prolongs allograft survival, is a co-drug with its intracellular receptor, FKBP12. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 2 | The FKBP12.FK506 complex inhibits calcineurin, a critical signaling molecule during T-cell activation. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 3 | FKBP12 was, until recently, the sole FKBP known to mediate calcineurin inhibition at clinically relevant FK506 concentrations. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 4 | In transfected Jurkat cells, FKBP12.6 is equivalent to FKBP12 at mediating the inhibitory effects of FK506. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |