Title : Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.

Pub. Date : 1995 Sep

PMID : 7591958






1 Functional Relationships(s)
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1 We found that ellipticine and 9-hydroxyellipticine (9HE), antitumor alkaloids, caused selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 microM. ellipticine tumor protein p53 Homo sapiens