Title : Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes.

Pub. Date : 1995 Oct

PMID : 7586124






2 Functional Relationships(s)
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1 The genetic basis for butadiene carcinogenicity is likely mediated by its metabolite, 1,2:3,4-diepoxybutane (BDE). 1,3-butadiene homeobox D13 Homo sapiens
2 Oxidation of butadiene to 1,2-epoxy-3-butene (BMO) and further activation to BDE is catalysed by cytochrome P450 (CYP) isozymes. 1,3-butadiene homeobox D13 Homo sapiens