Title : Effect of bacterial endotoxin and interleukin-1 on prostaglandin biosynthesis by the hippocampus of mouse brain: role of interleukin-1 receptors and glucocorticoids.

Pub. Date : 1995 Jul

PMID : 7566437






8 Functional Relationships(s)
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1 In the present study we examined the effect of the bacterial endotoxin lipopolysaccharide (LPS) and interleukin-1 (IL-1) on the ex vivo production of PGE2 by the dorsal hippocampus of the mouse which contains high levels of receptors to IL-1. Dinoprostone interleukin 1 complex Mus musculus
2 In the present study we examined the effect of the bacterial endotoxin lipopolysaccharide (LPS) and interleukin-1 (IL-1) on the ex vivo production of PGE2 by the dorsal hippocampus of the mouse which contains high levels of receptors to IL-1. Dinoprostone interleukin 1 complex Mus musculus
3 The roles of IL-1 receptors and GC in the regulation of LPS- or IL-1-induced PGE2 production were also studied. Dinoprostone interleukin 1 complex Mus musculus
4 The roles of IL-1 receptors and GC in the regulation of LPS- or IL-1-induced PGE2 production were also studied. Dinoprostone interleukin 1 complex Mus musculus
5 In mice treated with the IL-1 receptor antagonist or with the IL-1 antagonist alpha-melanocyte-stimulating hormone (alpha-MSH), the effects of LPS and IL-1 on PGE2 production were completely abolished. Dinoprostone interleukin 1 complex Mus musculus
6 In mice treated with the IL-1 receptor antagonist or with the IL-1 antagonist alpha-melanocyte-stimulating hormone (alpha-MSH), the effects of LPS and IL-1 on PGE2 production were completely abolished. Dinoprostone interleukin 1 complex Mus musculus
7 In mice treated with the IL-1 receptor antagonist or with the IL-1 antagonist alpha-melanocyte-stimulating hormone (alpha-MSH), the effects of LPS and IL-1 on PGE2 production were completely abolished. Dinoprostone interleukin 1 complex Mus musculus
8 In mice treated with 100 micrograms DEX/mouse, the facilitatory effect of the lower DEX does in IL-1-induced PGE2 production was abolished. Dinoprostone interleukin 1 complex Mus musculus