Title : Augmentation by aphidicolin of 1-beta-D-arabinofuranosylcytosine-induced c-jun and NF-kappa B activation in a human myeloid leukemia cell line: correlation with apoptosis.

Pub. Date : 1995 Sep

PMID : 7564475






4 Functional Relationships(s)
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1 Augmentation by aphidicolin of 1-beta-D-arabinofuranosylcytosine-induced c-jun and NF-kappa B activation in a human myeloid leukemia cell line: correlation with apoptosis. Aphidicolin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Although aphidicolin itself had a marginal effect on c-jun expression, it significantly augmented ara-C induced c-jun upregulation by shortening the lag time and lowering ara-C concentrations necessary for the induction of detectable c-jun transcripts. Aphidicolin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Although aphidicolin itself had a marginal effect on c-jun expression, it significantly augmented ara-C induced c-jun upregulation by shortening the lag time and lowering ara-C concentrations necessary for the induction of detectable c-jun transcripts. Aphidicolin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Thus, the activation of NF-kappa B and c-jun expression seems to be well correlated with the potentiation by aphidicolin of ara-C-induced apoptosis. Aphidicolin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens