Pub. Date : 1995 Oct 20
PMID : 7559663
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Effects of 12-O-tetradecanoylphorbol-13-acetate on estrogen receptor activity in MCF-7 cells. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
2 | The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
3 | The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
4 | The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
5 | The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
6 | Treatment of cells with 100 nM TPA resulted in an 80% decrease in the level of ER protein and a parallel decrease in ER mRNA and binding capacity. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
7 | Treatment of cells with 100 nM TPA resulted in an 80% decrease in the level of ER protein and a parallel decrease in ER mRNA and binding capacity. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
8 | Following removal of TPA from the medium, the level of ER protein and mRNA returned to control values; however, the receptor failed to bind estradiol. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
9 | In addition, TPA treatment blocked transcription from an estrogen response element in transient transfection assays and inhibited ER binding to its response element in a DNA mobility shift assay. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
10 | Mixing experiments suggest that TPA induces/activates a factor which interacts with the ER to block binding of estradiol. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |
11 | The effects of TPA on ER levels and binding capacity were concentration-dependent. | Tetradecanoylphorbol Acetate | estrogen receptor 1 | Homo sapiens |