Title : Localized chemical reactivity in double-stranded DNA associated with the intercalative binding of benzo[e]pyridoindole and benzo[g]pyridoindole triple-helix-stabilizing ligands.

Pub. Date : 1995 Aug 15

PMID : 7556172






3 Functional Relationships(s)
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Protein Name
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1 With potassium permanganate and osmium tetroxide/pyridine, probes for the accessibility of the 5,6 double bond of pyrimidine residues, BgPI has a more potent effect than BePI and, generally, the reaction with KMnO4 is more pronounced than that with OsO4. Osmium Tetroxide CEA cell adhesion molecule 1 Homo sapiens
2 With potassium permanganate and osmium tetroxide/pyridine, probes for the accessibility of the 5,6 double bond of pyrimidine residues, BgPI has a more potent effect than BePI and, generally, the reaction with KMnO4 is more pronounced than that with OsO4. Osmium Tetroxide CEA cell adhesion molecule 1 Homo sapiens
3 BgPI conspicuously potentiates the oxidation of pyrimidines in the triplet sequences 3"-ATA, 3"-GTA and 3"-GCA, whereas BePI enhances the reactivity of OsO4 towards thymine in sequences 3"-ATYR, with no effect on cytosine residues. Osmium Tetroxide CEA cell adhesion molecule 1 Homo sapiens