Pub. Date : 1995 Apr 24
PMID : 7552251
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our previous studies have indicated a critical role of protein kinase C (PKC) in intracellular mechanisms of tolerance to morphine analgesia. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | In the present experiments, we examined (1) the cellular distribution of a PKC isoform (PKC gamma) in the spinal cord dorsal horn of rats associated with morphine tolerance by utilizing an immunocytochemical method and (2) the effects of the N-methyl-D-aspartate receptor antagonist MK-801 on tolerance-associated PKC gamma changes. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | In the present experiments, we examined (1) the cellular distribution of a PKC isoform (PKC gamma) in the spinal cord dorsal horn of rats associated with morphine tolerance by utilizing an immunocytochemical method and (2) the effects of the N-methyl-D-aspartate receptor antagonist MK-801 on tolerance-associated PKC gamma changes. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | In association with the development of tolerance to morphine analgesia induced by once daily intrathecal administration of 10 micrograms morphine for eight days, PKC gamma immunoreactivity was clearly increased in the spinal cord dorsal horn of these same rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | In association with the development of tolerance to morphine analgesia induced by once daily intrathecal administration of 10 micrograms morphine for eight days, PKC gamma immunoreactivity was clearly increased in the spinal cord dorsal horn of these same rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | Within the spinal cord dorsal horn of morphine tolerant rats, there were significantly more PKC gamma immunostained neurons in laminae I-II than in laminae III-IV and V-VI. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 7 | Moreover, both the development of morphine tolerance and the increase in PKC gamma immunoreactivity were prevented by co-administration of morphine with 10 nmol MK-801 between Day 2 and Day 7 of the eight day treatment schedule. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 8 | These results provide further evidence for the involvement of PKC in NMDA receptor-mediated mechanisms of morphine tolerance. | Morphine | protein kinase C, gamma | Rattus norvegicus |