Title : Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs.

Pub. Date : 1995 Apr

PMID : 7547677






1 Functional Relationships(s)
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1 Paradoxically, drugs that effectively inhibit expression of TNF-alpha via the elevation of intracellular cAMP level (iloprost, pentoxifylline, prostaglandin E2 and N6,2-O-dibutyryl cAMP) augmented the endotoxin-induced IL-10 synthesis at both protein and mRNA levels. Bucladesine tumor necrosis factor Homo sapiens