Title : A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone.

Pub. Date : 1995 Jun

PMID : 7545821






1 Functional Relationships(s)
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1 The hydroxylation of the new antipsychotic drug risperidone to its main, active metabolite 9-hydroxyrisperidone is catalyzed by the hepatic cytochrome P450 enzyme CYP2D6, and cosegregates with the polymorphic hydroxylation of debrisoquin. Paliperidone Palmitate cytochrome P450 family 2 subfamily D member 6 Homo sapiens