Title : Possible involvement of tyrosine kinase in the LPS-promoted initiation of L-arginine-induced relaxation of rat aorta mediated by induction of no synthase.

Pub. Date : 1995

PMID : 7544862






4 Functional Relationships(s)
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1 Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries. Arginine interleukin 1 beta Rattus norvegicus
2 Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries. Arginine interleukin 1 beta Rattus norvegicus
3 In addition, in the aortic smooth muscle cells cultured in the presence of Arg, LPS- or IL-1 beta-triggered accumulation of nitrite was suppressed by the tyrosine kinase inhibitors. Arginine interleukin 1 beta Rattus norvegicus
4 These results suggest that tyrosine kinase is involved in the LPS- and IL-1 beta-promoted induction of nitric oxide synthase in the vascular smooth muscle, which in turn mediates production of NO from added Arg, thus stimulating formation of cGMP and causing relaxation. Arginine interleukin 1 beta Rattus norvegicus