Pub. Date : 1995 Jul 3
PMID : 7542586
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that in mammalian cells activation of p74Raf-1 by oncogenic Src requires pp60Src to be myristoylated and the ability of p74Raf-1 to interact with p21Ras-GTP. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |
| 2 | The Ras/Raf interaction is required for p21Ras-GTP to bring p74Raf-1 to the plasma membrane for phosphorylation at tyrosine 340 or 341, probably by membrane-bound pp60Src. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |
| 3 | Thus, p21Ras-GTP is the limiting component in bringing p74Raf-1 to the plasma membrane for tyrosine phosphorylation. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |
| 4 | Using mutants of Raf-1 at Tyr340/341, we show that in addition to tyrosine phosphorylation at these sites, there is an additional activation step resulting from p21Ras-GTP recruiting p74Raf-1 to the plasma membrane. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |