Pub. Date : 1995 Feb
PMID : 7532989
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on functional and sequence homology studies, it was recently discovered that hsp56 also belongs to the FKBP class of immunophilin proteins, which are thought to mediate the actions of the immunosuppressive drugs FK506 and rapamycin. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 2 | It was also found that the untransformed but not the transformed GR was retained following affinity chromatography with FK506-affigel resin, reinforcing the possibility that hsp56 within the untransformed GR complex could be a target for the actions of FK506. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 3 | Although we speculate that these actions of FK506 on the GR complex are mediated by the associated hsp56 component, other possible mechanisms are also discussed. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |