Title : Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction.

Pub. Date : 1995 Feb 17

PMID : 7531699






1 Functional Relationships(s)
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1 Previous reports have shown that 1) dsRNA, a direct activator of PKR, induces the genes c-myc, c-fos, and JE; 2) 2-aminopurine, a chemical inhibitor of PKR, blocks the induction of these genes by serum; and 3) activated p21ras induces a cellular inhibitor of PKR. 2-Aminopurine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens