Title : Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

Pub. Date : 1994 Oct 1

PMID : 7523573






2 Functional Relationships(s)
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1 Crosslinking of CD95 with DX2 resulted in the activation of a sphingomyelinase (SMase) in promyelocytic U937 cells, as well as in other human tumor cell lines and in CD95-transfected murine cells, as demonstrated by induction of in vivo sphingomyelin (SM) hydrolysis and generation of ceramide. Sphingomyelins Fas cell surface death receptor Homo sapiens
2 Crosslinking of CD95 with DX2 resulted in the activation of a sphingomyelinase (SMase) in promyelocytic U937 cells, as well as in other human tumor cell lines and in CD95-transfected murine cells, as demonstrated by induction of in vivo sphingomyelin (SM) hydrolysis and generation of ceramide. Sphingomyelins Fas cell surface death receptor Homo sapiens