Title : Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.

Pub. Date : 1994 Sep 6

PMID : 7521210






2 Functional Relationships(s)
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1 To gain insight into the mechanism of FK506"s regulation of PR action, we questioned whether calcineurin is involved, because it has been shown that FK506 is a specific inhibitor of calcineurin, a Ca(2+)- and calmodulin-regulated phosphatase, through the formation of an FKBP12-FK506-calcineurin-calmodulin complex. Tacrolimus FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens
2 To gain insight into the mechanism of FK506"s regulation of PR action, we questioned whether calcineurin is involved, because it has been shown that FK506 is a specific inhibitor of calcineurin, a Ca(2+)- and calmodulin-regulated phosphatase, through the formation of an FKBP12-FK506-calcineurin-calmodulin complex. Tacrolimus FKBP prolyl isomerase 1A pseudogene 1 Homo sapiens