Title : Inhibition of lipopolysaccharide and IL-1 but not of TNF-induced activation of human endothelial cells by suramin.

Pub. Date : 1994 Sep 1

PMID : 7519646






3 Functional Relationships(s)
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1 This study investigates the ability of the experimental drug suramin to block the activation of HUVEC by endotoxin and by the proinflammatory cytokines IL-1 and TNF. Suramin interleukin 1 beta Homo sapiens
2 We demonstrate that the inducible expression of several adhesion molecules by LPS and IL-1 beta but not by TNF-alpha is prevented by suramin. Suramin interleukin 1 beta Homo sapiens
3 In a dose-dependent manner, suramin inhibits the binding of neutrophils and T lymphocytes to LPS and IL-1 beta but not to TNF-alpha-activated HUVEC. Suramin interleukin 1 beta Homo sapiens