Title : Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential.

Pub. Date : 1994 Aug

PMID : 7518822






5 Functional Relationships(s)
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1 Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential. Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens
2 In addition, the ability to bind and degrade hyaluronan was restricted to the cell lines expressing high levels of CD44, and both these functions were blocked by an antibody to CD44 (Hermes-1). Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens
3 In addition, the ability to bind and degrade hyaluronan was restricted to the cell lines expressing high levels of CD44, and both these functions were blocked by an antibody to CD44 (Hermes-1). Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens
4 Moreover, the rate of [3H]hyaluronan degradation was highly correlated with the amount of CD44 (r = 0.951, P < 0.0001), as well as with the invasive potential of the cells. Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens
5 These results illustrate the diversity of CD44 molecules in invasive tumor cells, and suggest that one of their major functions is to degrade hyaluronan. Hyaluronic Acid CD44 molecule (Indian blood group) Homo sapiens