Pub. Date : 1994 Apr
PMID : 7512046
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amelioration of azidothymidine-induced erythroid toxicity by hemin and stem cell factor in immune-suppressed mice. | Zidovudine | kit ligand | Mus musculus |
| 2 | We reasoned that hemin, previously shown to both enhance BFU-E proliferation and accelerate erythroid maturation, might bring about differentiation of this large SCF-induced pool of BFU-E and further protect BFU-E from AZT"s toxic effect. | Zidovudine | kit ligand | Mus musculus |
| 3 | 50 microM hemin increased the ED50 of AZT from 1 x 10(-7) M to 1.7 x 10(-6) M. SCF also ameliorated AZT-induced toxicity, but to a lesser extent. | Zidovudine | kit ligand | Mus musculus |
| 4 | 50 microM hemin increased the ED50 of AZT from 1 x 10(-7) M to 1.7 x 10(-6) M. SCF also ameliorated AZT-induced toxicity, but to a lesser extent. | Zidovudine | kit ligand | Mus musculus |
| 5 | SCF and hemin increased the number of BFU-E colonies observed in the presence of AZT in an additive fashion. | Zidovudine | kit ligand | Mus musculus |
| 6 | The resistance of BFU-E to AZT"s cytotoxic effect was greater in cultures receiving hemin and SCF together than in cultures receiving SCF or hemin alone. | Zidovudine | kit ligand | Mus musculus |
| 7 | The resistance of BFU-E to AZT"s cytotoxic effect was greater in cultures receiving hemin and SCF together than in cultures receiving SCF or hemin alone. | Zidovudine | kit ligand | Mus musculus |
| 8 | Combinations of SCF and hemin may prove useful in ameliorating AZT toxicity in both immune-suppressed mice and human immunodeficiency virus (HIV)-infected patients. | Zidovudine | kit ligand | Mus musculus |