Title : Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

Pub. Date : 1994 Feb 11

PMID : 7508445






2 Functional Relationships(s)
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1 A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras. cho insulin Cricetulus griseus
2 A CHO cell line overexpressing the mutant insulin receptor, substituting Ala960 for Tyr960 and which was known to exhibit impaired tyrosine phosphorylation of IRS-1 and biological effects evoked by insulin, showed severely impaired insulin-dependent tyrosine phosphorylation of Shc and moderately impaired activation of Ras. cho insulin Cricetulus griseus