Title : Cyclic AMP regulation of messenger RNA level of the stimulatory GTP-binding protein Gs alpha. Isoproterenol, forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate increase the level of Gs alpha mRNA in cultured astroglial cells.

Pub. Date : 1994 Jan 15

PMID : 7508389






3 Functional Relationships(s)
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1 Isoproterenol, forskolin and 8-bromoadenosine 3":5"-cyclic monophosphate increase the level of Gs alpha mRNA in cultured astroglial cells. Colforsin GNAS complex locus Homo sapiens
2 The culture of astroglial cells with isoproterenol or forskolin (3-24 h) resulted in a transient increase of both the Gs alpha and the Gi alpha protein levels, while the level of G beta subunits was unaffected. Colforsin GNAS complex locus Homo sapiens
3 The level of Gs alpha mRNA measured by Northern-blot analysis was transiently increased (200%) after stimulation of astroglial cells with isoproterenol or forskolin for an incubation period of 6-9 h, then returned to that of control cells for longer period of time. Colforsin GNAS complex locus Homo sapiens