Title : Prostacyclin analogs suppress the synthesis of tumor necrosis factor-alpha in LPS-stimulated human peripheral blood mononuclear cells.

Pub. Date : 1993 Nov-Dec

PMID : 7507098






2 Functional Relationships(s)
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1 Our results show, that the stable analogs of PGI2, iloprost and cicaprost, markedly suppress TNF-alpha synthesis in LPS-stimulated MNC without effect on IL-1 beta production. cicaprost tumor necrosis factor Homo sapiens
2 Suppression of TNF-alpha synthesis by cicaprost and PGE2 is probably mediated by an increased intracellular cAMP formation. cicaprost tumor necrosis factor Homo sapiens