Title : Effect of pindolol pretreatment on MK-212-induced plasma cortisol and prolactin responses in normal men.

Pub. Date : 1995 Sep 1

PMID : 7495925






2 Functional Relationships(s)
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1 These data suggest that the MK-212-induced cortisol response may be mediated by 5-HT2A or 5-HT2C receptor activation, or both, despite 5-HT1A inhibition; however, PRL secretion by MK-212 requires 5-HT1A receptor availability as well as 5-HT2A/5-HT2C receptor activation, since blockade of the former appears to blunt the PRL responses to MK-212. 6-chloro-2-(1-piperazinyl)pyrazine 5-hydroxytryptamine receptor 1A Homo sapiens
2 These data suggest that the MK-212-induced cortisol response may be mediated by 5-HT2A or 5-HT2C receptor activation, or both, despite 5-HT1A inhibition; however, PRL secretion by MK-212 requires 5-HT1A receptor availability as well as 5-HT2A/5-HT2C receptor activation, since blockade of the former appears to blunt the PRL responses to MK-212. 6-chloro-2-(1-piperazinyl)pyrazine 5-hydroxytryptamine receptor 1A Homo sapiens