Title : Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract.

Pub. Date : 1995 Dec

PMID : 7493028






7 Functional Relationships(s)
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1 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
2 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
3 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
4 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
5 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
6 The synthesis of ferritin, the iron-storing molecule, is regulated at the translational level by iron through interaction between a cytoplasmic protein, iron regulatory protein (IRP), and a conserved nucleotide motif present in the 5" non-coding region of all ferritin mRNAs--the iron responsive element (IRE). Iron Wnt family member 2 Homo sapiens
7 This region forms a stem-loop structure and when the supply of iron to the cells is limited, the IRP is bound to IRE and represses ferritin synthesis. Iron Wnt family member 2 Homo sapiens