Title : Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

Pub. Date : 1995 Nov 24

PMID : 7490734






1 Functional Relationships(s)
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1 The PDE IV inhibitor 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724, 2) was used as a template from which to design a set of rigid oxazolidinones, imidazolidinones, and pyrrolizidinones that mimic Ro 20-1724 but differ in the orientation of the carbonyl group. 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone aldehyde dehydrogenase 7 family member A1 Homo sapiens