Title : Porphyrin pi-cation and protein radicals in peroxidase catalysis and inhibition by anti-thyroid chemicals.

Pub. Date : 1995 Jul

PMID : 7483672






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Methimazole, a therapeutic, anti-hyperthyroid drug, is a suicide substrate for TPO and effects irreversible inactivation by TPO-mediated S-oxygenation to a reactive sulphenic acid that binds covalently to the prosthetic haem. Methimazole thyroid peroxidase Homo sapiens
2 Methimazole, a therapeutic, anti-hyperthyroid drug, is a suicide substrate for TPO and effects irreversible inactivation by TPO-mediated S-oxygenation to a reactive sulphenic acid that binds covalently to the prosthetic haem. Methimazole thyroid peroxidase Homo sapiens