Title : Aminium cation radical mechanism proposed for monoamine oxidase B catalysis: are there alternatives?

Pub. Date : 1995 Jul

PMID : 7483670






4 Functional Relationships(s)
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1 The interaction of bovine liver mitochondrial monoamine oxidase B (MAO B) with a series of benzylamine analogues was investigated to provide mechanistic information relative to the proposed cation radical mechanism and to provide information on the structural requirements of the substrate binding site. benzylamine monoamine oxidase B Bos taurus
2 The interaction of bovine liver mitochondrial monoamine oxidase B (MAO B) with a series of benzylamine analogues was investigated to provide mechanistic information relative to the proposed cation radical mechanism and to provide information on the structural requirements of the substrate binding site. benzylamine monoamine oxidase B Bos taurus
3 Steady-state kinetic analysis of MAO B with 11 ring-substituted benzylamine analogues showed substitution does not alter the reaction pathway. benzylamine monoamine oxidase B Bos taurus
4 The binding affinity of para-substituted benzylamine analogues to MAO B increased as the hydrophobicity of the substituent increased. benzylamine monoamine oxidase B Bos taurus