Title : Activation of Src family kinases in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo.

Pub. Date : 1995 Nov 2

PMID : 7478608






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Studies with Rat.2 fibroblasts overexpressing activated Neu revealed that c-Src requires the presence of tyrosine phosphorylated Neu for its ability to interact with Neu in vivo. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 Although both c-Src and c-Yes kinase associate with Neu in vivo, a tyrosine phosphorylated protein of 89 kd (p89) was found associated with c-Src but not with c-Yes in cell lysates derived from mammary epithelial cells transformed by either Neu or PyV middle T antigen. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
3 Furthermore, this tyrosine phosphorylated protein was not detected in c-Src complexes derived from fibroblasts transformed by either Neu or PyV middle T. These observations suggest that p89 associates with c-Src only in mammary epithelial cells and not in fibroblasts. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus