Title : Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

Pub. Date : 1995 Oct 5

PMID : 7478553






1 Functional Relationships(s)
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1 This modification of Sos does not alter its ability to bind Grb2, but correlates with strong inhibition of the binding of the Sos/Grb2 complex to tyrosine phosphorylated sequences, either a tyrosine phosphopeptide in cell lysates or p36 in intact cells. Tyrosine 5'-nucleotidase, cytosolic IIIA Homo sapiens