Title : Effect of local cholecystokinin-8 administration on extracellular levels of amino acids and glycolytic products monitored by in vivo microdialysis in the fronto-parietal cortex of the rat.

Pub. Date : 1995 Jul 14

PMID : 7478205






4 Functional Relationships(s)
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1 CCK-8 (10 microM), administrated via a microdialysis probe, produced a significant increase in the levels of aspartate, glutamate and gamma-aminobutyric acid (GABA), but not of 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), lactate and pyruvate, which were simultaneously monitored. gamma-Aminobutyric Acid cholecystokinin Rattus norvegicus
2 CCK-8 (10 microM), administrated via a microdialysis probe, produced a significant increase in the levels of aspartate, glutamate and gamma-aminobutyric acid (GABA), but not of 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), lactate and pyruvate, which were simultaneously monitored. gamma-Aminobutyric Acid cholecystokinin Rattus norvegicus
3 GABA was slightly, but significantly increased (approximately 30%), by local CCK-8 and was inhibited by both CCK antagonists. gamma-Aminobutyric Acid cholecystokinin Rattus norvegicus
4 GABA was slightly, but significantly increased (approximately 30%), by local CCK-8 and was inhibited by both CCK antagonists. gamma-Aminobutyric Acid cholecystokinin Rattus norvegicus