Title : Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes.

Pub. Date : 1995 Oct

PMID : 7476899






13 Functional Relationships(s)
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1 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
3 Ethanol dose-response analysis revealed enhanced inhibitory efficacy of ethanol in the presence of subsaturating glycine concentrations at the NR1/NR2A, NR1/NR2C, and NR1/NR2D receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
4 Glycine reversal of ethanol inhibition suggested that ethanol might lower the affinity of glycine for the NMDA receptor and thereby decrease response magnitude. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
5 Glycine reversal of ethanol inhibition suggested that ethanol might lower the affinity of glycine for the NMDA receptor and thereby decrease response magnitude. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
6 Consistent with this hypothesis, ethanol significantly reduced glycine affinity at NR1/NR2A and NR1/NR2C receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
7 Consistent with this hypothesis, ethanol significantly reduced glycine affinity at NR1/NR2A and NR1/NR2C receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
8 Activation of the NR1/NR2D heteromers by NMDA and low concentrations of glycine elicited responses characterized by an initial peak followed by a lower-amplitude plateau response, which is consistent with glycine-sensitive desensitization as previously described for native NMDA receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
9 Activation of the NR1/NR2D heteromers by NMDA and low concentrations of glycine elicited responses characterized by an initial peak followed by a lower-amplitude plateau response, which is consistent with glycine-sensitive desensitization as previously described for native NMDA receptors. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
10 In addition, nondesensitizing NR1/NR2B responses elicited in the presence of subsaturating concentrations of glycine were frequently converted into desensitizing responses by the addition of ethanol, an effect that was reversed with increasing glycine concentrations. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
11 In addition, nondesensitizing NR1/NR2B responses elicited in the presence of subsaturating concentrations of glycine were frequently converted into desensitizing responses by the addition of ethanol, an effect that was reversed with increasing glycine concentrations. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
12 The ability of ethanol to promote glycine-sensitive desensitization further suggests an interaction between glycine and ethanol inhibition of the NMDA receptor. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
13 The ability of ethanol to promote glycine-sensitive desensitization further suggests an interaction between glycine and ethanol inhibition of the NMDA receptor. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis