Pub. Date : 1980 Dec
PMID : 7462336
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of changes in the ionic environment of reticulocytes on the uptake of transferrin-bound iron. | Iron | serotransferrin | Oryctolagus cuniculus |
| 2 | It was concluded that low ionic strength inhibits iron uptake primarily by blocking the endocytosis of transferrin. | Iron | serotransferrin | Oryctolagus cuniculus |
| 3 | This action was due to an effect on the release of iron from transferrin, which appeared to be taken up by the cells in a normal manner. | Iron | serotransferrin | Oryctolagus cuniculus |
| 4 | However, with CaCl2 concentrations above 10 mM, iron uptake was inhibited, due to inhibition of transferrin uptake, possibly by blocking endocytosis. | Iron | serotransferrin | Oryctolagus cuniculus |
| 5 | The results are discussed in terms of the possible effects of ionic strength, pH, and ionic composition of the extracellular fluid on the three main steps involved in iron uptake by immature erythroid cells: transferrin-receptor interaction, endocytosis, and iron release from transferrin. | Iron | serotransferrin | Oryctolagus cuniculus |