Title : Adenylate cyclase activation and competitive binding with renal tissue using synthetic eel calcitonin analog and its fragments.

Pub. Date : 1981 Feb

PMID : 7449744






1 Functional Relationships(s)
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1 [Asu1,7]E-CT analog, synthesized by replacing the S-S bond of Cys1-Cys7 in the natural hormone with ethylene linkage of 1-amino suberic acid (Asu), and E-CT fragment 11-32 had about 1/5th and 1/50th the potencies of synthetic E-CT, respectively, in both adenylate cyclase activation and competitive inhibition of 125I-labeled [Asu1,7]iodo-E-CT binding on rat renal plasma membranes. CYS7 cystin 1 Rattus norvegicus