Title : Conformational analysis of nucleoside and nucleotide antibiotics prossessing five-membered base rings. A comparison of the glycosyl barrier for purine, pyrimidine and imidazole rings.

Pub. Date : 1980 Mar 28

PMID : 7370262






1 Functional Relationships(s)
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1 In the absence of any such hydrogen bonding, the imidazole nucleosides expectedly exhibit nearly "free" rotation around the glycosyl bond for the commonly found C(3") endo and C(2") endo sugar ring conformations, thus increasing the probability of anti in equilibrium high-anti in equilibrium syn conformational interconversions as compared to common purine and pyrimidine nucleosides. Sugars synemin Homo sapiens