Title : The pulmonary clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride.

Pub. Date : 1980 Jan

PMID : 7351618






1 Functional Relationships(s)
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1 Although it is not yet known whether cytochrome P-450 and benzphetamine demethylase activities are present in substantial amounts in more than one lung cell type in mice or rats, previous studies have indicated that cytochrome P-450 enzymes located in pulmonary bronchiolar Clara cells of these mediate the covalent binding of 4-ipomeanol to lung macromolecules. 4-ipomeanol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus