Title : Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Pub. Date : 1981 Jul 10

PMID : 7240242






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ML236B is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34), the major regulatory enzyme in cholesterol biosynthesis. Cholesterol 3-hydroxy-3-methylglutaryl-coenzyme A reductase Cricetulus griseus